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Back to top. Get to Know Us. If the blood pressure is permanently too high, here via the blood vessels are damaged. Folgeerkrankungen hieraus sind beispielsweise koronare Herzkrankheit, Angina pectoris, Herzinfarkt und Schlaganfall. Secondary diseases thereof, for example, coronary heart disease, angina pectoris, myocardial infarction and stroke. All these diseases are among the leading causes of death currently.
The reduction of elevated blood pressure can thus thus prevent many deaths. Hypertension is also recognized as a risk factor for the development of atherosclerosis vascular calcification. Hypertension is discriminated as primary and secondary form. It may itself be the cause of a disease primary hypertension , or the result of other underlying disease secondary hypertension.
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Their causes are considered multifactorial and it must be treated long lasting antihypertensive action. This may, for example inflammation or vasoconstriction in the kidney, but also disturbances in hormonal and mineral metabolism. The reduction of an already existing, increased blood pressure, on the one hand take place via General measures such. As by physical exercise, sports, weight loss, improve nutrition, or otherwise medically using so-called Antipypertonika.
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For this purpose include, but are most well-known groups called ACE inhibitors, beta blockers, diuretics, calcium antagonists. These medicinal measures are only symptomatic. In particular, however, these drugs show a significant number of adverse effects. Improvement of the spectrum of active agents, in particular those with better tolerability and safety, are therefore desirable. Der Erfindung liegt die Aufgabe zugrunde Bluthochdruck vorzubeugen oder zu senken.
The object of the invention is based on preventing high blood pressure or lower. This object is achieved in that pharmaceutical formulations are used as active ingredients trimagnesium dicitrate salt 2-hydroxypropane-1,2,3-tricarboxylic acid magnesium salt 2: 3, Mg 3 C 6 H 5 O 7 2 or Trimagnesiumdiisocitrat 1 contain 3 , wherein these substances may be present alone or in combination, and these are formed as a hydrate or anhydrate: -Hydroxypropan 1,2,3-tricarboxylic acid magnesium salt.
Um die Verwendung weiter zu spezifizieren, liegen, in einer weiteren Ausbildung der Erfindung, die Stoffe als gemischtes Magnesium-Kalium Citrat Salz, vor.
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In order to specify the use of further, are, in a further embodiment of the invention, the substances as a mixed magnesium-potassium citrate salt before. In order to widen the use as a pharmaceutical formulation tablets, effervescent tablets, chewable tablets, capsules, dragees, powders, effervescent powders, granules, solutions, emulsions, suspensions, infusions or injections used. In order to broaden the use of the pharmaceutical formulations in the human field and in the veterinary field are to be used.
One advantage of the invention is that it allows for the first time a pharmaceutical therapy for high blood pressure, which not only expands the vessels, but can also positively influence already calcified blood vessels. A medical therapy of substances trimagnesium dicitrate Mg 3 C 6 H 5 O 7 2 and Trimagnesiumdiisocitrat hereinafter collectively TMDC has so far not described or used for the indication of hypertension.
The indication newly found hypertension turned out for the active substance TMDC than surprising.
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She was also not obvious because it initially required a review of cellular mechanisms and creating a new therapeutic overall image. This results from the one hand from previous medication therapy developments, are following completely different routes for substances to treat high blood pressure. Opposite to this, the new indication is in a different plane of action. The effect creates a summary from the fact that, above all, the anionic citrate share of TMDC complex mitigates negative cell metabolic consequences.
The increased by an increased blood pressure Risk a Arterioklerose so califizierender vessel hardening is affected by TMDC engages by this in the relation elevated calcium ions and phosphates. Hence, there is a reduction of chemical reaction products calcium phosphate, hydroxyapatite acting degenerative calcifizierend of vessels. In the therapeutic effect, this results in a preservation or improvement of the operating conditions of the blood vessels.
Unlike other anti-hypertensives, located TMDC is through this long-term metabolic mechanism as a prophylactic measure, since it can be counteracted here on a long-term progressive vascular calcification with vascular hardening. The addition acute pharmacodynamic vasodilatory effect of TMDC in HET model appears here essentially to match the one alpha adrenergic blockade.
A significant advantage is that the TMDC complex has a high biological safety and tolerability.
The therapeutic range is significantly higher than that of other chemical antihypertensives. Thus, all components are biologically fully TMDC utilisiert, including in energy metabolism as a substrate in the citric acid cycle.