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Cutaneous Manifestations of Rheumatic Diseases

Clinical Cases in Cardiology. Alessandro Capucci. Core Topics in Thoracic Surgery. Marco Scarci. Minimally Invasive Thoracic and Cardiac Surgery. Rolf Gilbert Carl Inderbitzi. Vincenzo Mandala. Soft Tissue Tumors. Jerzy Klijanienko. Atlas of Ultrasonography in Urology, Andrology, and Nephrology. Pasquale Martino. Federico Venuta. Cesar A. Acute Gastrointestinal Bleeding. Karen E. Radiological Imaging of the Kidney. Emilio Quaia. Or filter your current search. Type: Review, Journal Article. Abstract Being the largest organ of the human body, skin is frequently affected in many rheumatic diseases. Thus, it can serve as an important indicator for the correct diagnosis of a rheumatic disease and also as a marker of disease activity in distinct rheumatic disorders. In this review we will highlight the clinical features of these cutaneous manifestations of the major rheumatic diseases.

We will also provide an update on the complex pathobiology of these diseases based on the most recent developments in clinical and translational research. How does Europe PMC derive its citations network? Protein Interactions. It can be distinguished from vasculitis through skin biopsies for haematoxylin and eosin, as well as direct immunofluorescence, according to Fernandez.

He added that the biopsy should include mm of marginal skin and an eventual ulcer. In addition, livedoid vasculopathy can be evaluated and identified through hypercoagulation screening panel. Contact dermatitis — both irritant and allergic types — are caused by the contact of various entities with the skin, and both types are morphologically indistinguishable from endogenous eczema, Fernandez noted. According to Fernandez, important factors to consider when distinguishing allergic contact dermatitis from dermatomyositis are that acute durations favor the dermatologic condition, while sunlight as an aggravating factor often, but not always, points to the rheumatic disease.

In addition, well-demarcated plaques and vesicles are most likely to suggest allergic contact dermatitis. Biopsy and laboratory results can also help determine a diagnosis.